Metabolism-Induced Toxicity of Selegiline and Carbamazepine Studied with an In Vitro Method
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چکیده
منابع مشابه
Metabolism-Induced Toxicity of Selegiline and Carbamazepine Studied with an In Vitro Method
Carbamazepine and selegiline, although neuroprotective themselves, are presumed to have toxic metabolites. The aim of this study was to investigate the possible metabolism-induced toxicity of selegiline and carbamazepine with a novel in vit ro method: The drugs were incubated with target cells (neuroblastoma SH-SY5Y) with or without a preincubation with mouse or human hepatocytes. The viability...
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15 صفحه اولPossible carbamazepine toxicity with terbinafine.
OBJECTIVE To report a case of carbamazepine and terbinafine interaction resulting in an elevated level of carbamazepine and associated symptoms of toxicity. CASE SUMMARY A 50-year-old Caucasian man developed an elevated carbamazapine level after starting terbinafine, which caused symptoms of toxicity with gait ataxia, dizziness and falls. DISCUSSION This is a first report of a drug-drug int...
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Acetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophe...
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ژورنال
عنوان ژورنال: The Open Toxicology Journal
سال: 2008
ISSN: 1874-3404
DOI: 10.2174/1874340400802010061